The authors found that Picornaviridae was the only family showing a significant difference between exposed and non-exposed proteins (R2 = 0.207, P = 0.0044). We should keep in mind that Picornaviridae is the largest family in the dataset (n = 48). The lack of significance in other families is likely just a lack of statistical power rather than a real biological difference, and this should be discussed.
This is a fair criticism and we can revise the corresponding part of the manuscript to acknowledge that differences in sample size (number of viruses per family) are an issue.
This is a fair criticism and we can revise the corresponding part of the manuscript to acknowledge that differences in sample size (number of viruses per family) are an issue.