diff --git a/lib/internal/test_runner/mock/loader.js b/lib/internal/test_runner/mock/loader.js
index d64ffdfa096559..4deedd695f06c3 100644
--- a/lib/internal/test_runner/mock/loader.js
+++ b/lib/internal/test_runner/mock/loader.js
@@ -1,7 +1,10 @@
 'use strict';
 const {
+  ArrayPrototypePop,
+  ArrayPrototypePush,
   JSONStringify,
   SafeMap,
+  SafeSet,
 } = primordials;
 
 const kMockSearchParam = 'node-test-mock';
@@ -14,6 +17,34 @@ let debug = require('internal/util/debuglog').debuglog('test_runner', (fn) => {
 });
 
 const mocks = new SafeMap();
+const moduleImporters = new SafeMap();
+
+/**
+ * @param {string} url Resolved URL of the module to start from.
+ * @returns {SafeSet} The set of importer URLs.
+ */
+function collectMockDependents(url) {
+  const dependents = new SafeSet();
+  const queue = [url];
+
+  while (queue.length > 0) {
+    const current = ArrayPrototypePop(queue);
+    const importers = moduleImporters.get(current);
+
+    if (importers === undefined) {
+      continue;
+    }
+
+    for (const importer of importers) {
+      if (!dependents.has(importer)) {
+        dependents.add(importer);
+        ArrayPrototypePush(queue, importer);
+      }
+    }
+  }
+
+  return dependents;
+}
 
 function resolve(specifier, context, nextResolve) {
   debug('resolve hook entry, specifier = "%s", context = %o', specifier, context);
@@ -21,6 +52,15 @@ function resolve(specifier, context, nextResolve) {
   const nextResolveResult = nextResolve(specifier, context);
   const mockSpecifier = nextResolveResult.url;
 
+  if (context.parentURL !== undefined) {
+    const importers = moduleImporters.get(mockSpecifier);
+    if (importers === undefined) {
+      moduleImporters.set(mockSpecifier, new SafeSet([context.parentURL]));
+    } else {
+      importers.add(context.parentURL);
+    }
+  }
+
   const mock = mocks.get(mockSpecifier);
   debug('resolve hook, specifier = "%s", mock = %o', specifier, mock);
 
@@ -144,6 +184,7 @@ if (module.exports === null || typeof module.exports !== 'object') {
 }
 
 module.exports = {
+  collectMockDependents,
   hooks: { __proto__: null, load, resolve },
   mocks,
   constants: {
diff --git a/lib/internal/test_runner/mock/mock.js b/lib/internal/test_runner/mock/mock.js
index 970356bcae3aa0..c0c1c7652ccfc4 100644
--- a/lib/internal/test_runner/mock/mock.js
+++ b/lib/internal/test_runner/mock/mock.js
@@ -84,6 +84,7 @@ const deprecateDefaultExport = deprecateProperty(
   'mock.module(): options.defaultExport is deprecated. Use options.exports.default instead.',
 );
 const {
+  collectMockDependents,
   hooks: mockHooks,
   mocks,
   constants: { kBadExportsMessage, kMockSearchParam },
@@ -261,6 +262,14 @@ class MockModuleContext {
       __proto__: null,
       moduleExports,
     });
+    this.#evictDependents(baseURL);
+  }
+
+  #evictDependents(baseURL) {
+    const { loadCache } = this.#sharedState.moduleLoader;
+    for (const dependent of collectMockDependents(baseURL)) {
+      loadCache.delete(dependent);
+    }
   }
 
   restore() {
@@ -282,6 +291,7 @@ class MockModuleContext {
       mock.active = false;
       mock.localVersion++;
     }
+    this.#evictDependents(this.#restore.baseURL);
 
     this.#sharedState.mockMap.delete(this.#restore.baseURL);
     this.#sharedState.mockMap.delete(this.#restore.fullPath);
diff --git a/test/fixtures/module-mocking/reset-consumer-b.mjs b/test/fixtures/module-mocking/reset-consumer-b.mjs
new file mode 100644
index 00000000000000..07d21e38d60259
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-consumer-b.mjs
@@ -0,0 +1,5 @@
+import dependency from './reset-dependency.mjs';
+
+export default function consumerB() {
+  return dependency();
+}
diff --git a/test/fixtures/module-mocking/reset-consumer.mjs b/test/fixtures/module-mocking/reset-consumer.mjs
new file mode 100644
index 00000000000000..8ce363b8f5a2fd
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-consumer.mjs
@@ -0,0 +1,5 @@
+import dependency from './reset-dependency.mjs';
+
+export default function consumer() {
+  return dependency();
+}
diff --git a/test/fixtures/module-mocking/reset-dependency.mjs b/test/fixtures/module-mocking/reset-dependency.mjs
new file mode 100644
index 00000000000000..fcea2bb8fa9085
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-dependency.mjs
@@ -0,0 +1,3 @@
+export default function dependency() {
+  return 'original dependency';
+}
diff --git a/test/fixtures/module-mocking/reset-named-consumer.mjs b/test/fixtures/module-mocking/reset-named-consumer.mjs
new file mode 100644
index 00000000000000..bdc3be36730dab
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-named-consumer.mjs
@@ -0,0 +1,5 @@
+import { readValue } from './reset-named-dependency.mjs';
+
+export function run() {
+  return readValue();
+}
diff --git a/test/fixtures/module-mocking/reset-named-dependency.mjs b/test/fixtures/module-mocking/reset-named-dependency.mjs
new file mode 100644
index 00000000000000..06cf2a10f97dca
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-named-dependency.mjs
@@ -0,0 +1,3 @@
+export function readValue() {
+  return 'original value';
+}
diff --git a/test/fixtures/module-mocking/reset-nested-consumer.mjs b/test/fixtures/module-mocking/reset-nested-consumer.mjs
new file mode 100644
index 00000000000000..e3d1b2bfc691af
--- /dev/null
+++ b/test/fixtures/module-mocking/reset-nested-consumer.mjs
@@ -0,0 +1,5 @@
+import consumer from './reset-consumer.mjs';
+
+export default function nestedConsumer() {
+  return consumer();
+}
diff --git a/test/parallel/test-runner-module-mocking.js b/test/parallel/test-runner-module-mocking.js
index 7f2c76663ba29c..67d6388be4a382 100644
--- a/test/parallel/test-runner-module-mocking.js
+++ b/test/parallel/test-runner-module-mocking.js
@@ -10,7 +10,7 @@ if (!isMainThread) {
 const fixtures = require('../common/fixtures');
 const assert = require('node:assert');
 const { relative } = require('node:path');
-const { test } = require('node:test');
+const { beforeEach, describe, mock, test } = require('node:test');
 const { pathToFileURL } = require('node:url');
 
 test('input validation', async (t) => {
@@ -553,6 +553,125 @@ test('mocks can be restored independently', async (t) => {
   assert.strictEqual(esmImpl.fn, undefined);
 });
 
+// Refs https://github.com/nodejs/node/issues/59163
+test('re-mocking a dependency resets consumers imported in earlier tests', async (t) => {
+  const dependency = fixtures.fileURL('module-mocking', 'reset-dependency.mjs');
+  const consumer = fixtures.fileURL('module-mocking', 'reset-consumer.mjs');
+  const nestedConsumer = fixtures.fileURL('module-mocking', 'reset-nested-consumer.mjs');
+
+  await t.test('direct consumer uses the first mock', async (t) => {
+    const mockDependency = t.mock.fn(() => 'first mock');
+    t.mock.module(dependency, { defaultExport: mockDependency });
+
+    const { default: consume } = await import(consumer);
+
+    assert.strictEqual(consume(), 'first mock');
+    assert.strictEqual(mockDependency.mock.callCount(), 1);
+  });
+
+  await t.test('direct consumer uses the second mock', async (t) => {
+    const mockDependency = t.mock.fn(() => 'second mock');
+    t.mock.module(dependency, { defaultExport: mockDependency });
+
+    const { default: consume } = await import(consumer);
+
+    assert.strictEqual(consume(), 'second mock');
+    assert.strictEqual(mockDependency.mock.callCount(), 1);
+  });
+
+  await t.test('transitive consumer uses a fresh mock', async (t) => {
+    const mockDependency = t.mock.fn(() => 'third mock');
+    t.mock.module(dependency, { defaultExport: mockDependency });
+
+    const { default: consume } = await import(nestedConsumer);
+
+    assert.strictEqual(consume(), 'third mock');
+    assert.strictEqual(mockDependency.mock.callCount(), 1);
+  });
+
+  // After all mocks are restored, the consumers see the original dependency.
+  assert.strictEqual((await import(consumer)).default(), 'original dependency');
+  assert.strictEqual((await import(nestedConsumer)).default(), 'original dependency');
+});
+
+test('re-mocking a dependency refreshes every importer', async (t) => {
+  const dependency = fixtures.fileURL('module-mocking', 'reset-dependency.mjs');
+  const consumerA = fixtures.fileURL('module-mocking', 'reset-consumer.mjs');
+  const consumerB = fixtures.fileURL('module-mocking', 'reset-consumer-b.mjs');
+
+  await t.test('first mock reaches both importers', async (t) => {
+    t.mock.module(dependency, { exports: { default: () => 'first' } });
+
+    assert.strictEqual((await import(consumerA)).default(), 'first');
+    assert.strictEqual((await import(consumerB)).default(), 'first');
+  });
+
+  await t.test('second mock reaches both importers', async (t) => {
+    t.mock.module(dependency, { exports: { default: () => 'second' } });
+
+    assert.strictEqual((await import(consumerA)).default(), 'second');
+    assert.strictEqual((await import(consumerB)).default(), 'second');
+  });
+});
+
+test('restoring a mock re-exposes the original module', async (t) => {
+  const dependency = fixtures.fileURL('module-mocking', 'reset-dependency.mjs');
+  const consumer = fixtures.fileURL('module-mocking', 'reset-consumer.mjs');
+
+  const mocked = t.mock.module(dependency, { exports: { default: () => 'mocked' } });
+  assert.strictEqual((await import(consumer)).default(), 'mocked');
+
+  mocked.restore();
+  assert.strictEqual((await import(consumer)).default(), 'original dependency');
+});
+
+// Refs https://github.com/nodejs/node/issues/59163
+test('mocking a dependency refreshes consumers imported without a mock', async (t) => {
+  const dependency = fixtures.fileURL('module-mocking', 'reset-dependency.mjs');
+  const consumer = fixtures.fileURL('module-mocking', 'reset-consumer.mjs');
+
+  t.mock.module(dependency, { exports: { default: () => 'warm up' } });
+  t.mock.reset();
+
+  await t.test('reads the original when unmocked', async (t) => {
+    assert.strictEqual((await import(consumer)).default(), 'original dependency');
+  });
+
+  await t.test('reads the mock installed afterwards', async (t) => {
+    t.mock.module(dependency, { exports: { default: () => 'installed later' } });
+    assert.strictEqual((await import(consumer)).default(), 'installed later');
+  });
+});
+
+describe('re-mocking named exports between tests', () => {
+  const dependency = fixtures.fileURL('module-mocking', 'reset-named-dependency.mjs');
+  const consumer = fixtures.fileURL('module-mocking', 'reset-named-consumer.mjs');
+
+  beforeEach(() => {
+    mock.restoreAll();
+  });
+
+  test('first test observes its own mock', async (t) => {
+    const readValue = t.mock.fn(() => 'first');
+    t.mock.module(dependency, { exports: { readValue } });
+
+    const { run } = await import(consumer);
+
+    assert.strictEqual(run(), 'first');
+    assert.strictEqual(readValue.mock.callCount(), 1);
+  });
+
+  test('second test observes its own mock', async (t) => {
+    const readValue = t.mock.fn(() => 'second');
+    t.mock.module(dependency, { exports: { readValue } });
+
+    const { run } = await import(consumer);
+
+    assert.strictEqual(run(), 'second');
+    assert.strictEqual(readValue.mock.callCount(), 1);
+  });
+});
+
 async function assertCoreModuleMockWorksInBothModuleSystems(t, specifier, options) {
   const coreMock = t.mock.module(specifier, options);